Hope Science

IP6 Research

 

The B vitamin-like IP6 is an intracellular messenger, which means that it facilitates communication and therefore interaction between the various organelles within the cell.

Because IP6 functions in this way there are a multitude of effects on our physiology and therefore our health.

The B vitamin inositol, which is the “I” in IP6, is a component of our cell membranes and therefore has pronounced effects on the health of cells. It is primarily for these reasons that there has been so much scientific investigation of IP6 and inositol.

With thousands of research papers on IP6 and inositol we are only able to highlight a few of them for you. You may visit www.pubmed.gov for all the published research.

The following information is for educational and research purposes only. This information has not been evaluated by the FDA and is not meant to diagnose, treat or cure any disease. In all cases of concern, please consult a licensed physician.

IP6 Health Research Links:

Phytate (myo-inositol hexaphosphate) and risk factors for osteoporosis. 2008 PMID: 19053869

A key role for phosphorylated inositol compounds in pancreatic beta-cell stimulus-secretion coupling. 2008 PMID: 18194673

Dietary factors and the risk of incident kidney stones in younger women: Nurses’ Health Study 2004 PMID: 15111375

“Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study.” 2010 PMID: 20152024  Read the entire study (PDF)

“IP6 in Cancer Therapy: Past, Present, and Future” (Read the entire paper PDF) 2009

Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. 2008 PMID: 18941459

Protection against cancer by dietary IP6 and inositol. 2006 PMID: 17044765

(IP6): a novel treatment for pancreatic cancer. 2005 PMID: 15919420

Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats. 2005 PMID: 16124063

Prostate Cancer and Inositol Hexaphosphate: Efficacy and Mechanisms.2005 PMID: 16080543

Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer 2003 PMID: 12846414

Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells. 2003 PMID: 14666663

Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic. 2003 PMID: 14608114

Suppression of DMBA-induced mouse skin tumor development by inositol hexaphosphate and its mode of action. 2003 PMID: 12925306

Anti-cancer function of phytic acid 2002

Phytic acid (IP6), novel broad spectrum anti-neoplastic agent: a systematic review 2002 PMID: 12594974

Effect of inositol hexaphosphate (IP6) on human normal and leukaemic haematopoietic cells 2002 PMID: 12028025

Inhibition of Skin Cancer by IP6 in Vivo: Initiation-Promotion Model 1999 PMID: 10625952

Mammary tumor inhibition by IP6: a review  1999 PMID: 10625937

Metabolism and Cellular Functions of IP6 1999 PMID: 10625949

IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice 1998 PMID: 9891450

Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo 1998 PMID: 9673344

The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism. 2005 PMID: 15999878

Phosphorylated inositol compounds in beta -cell stimulus-response coupling. 2002 PMID: 12424101

Phytate (Myo-inositol hexakisphosphate) inhibits cardiovascular calcifications in rats.  2006 PMID: 16146720

Antiplatelet activity of inositol hexaphosphate (IP6) 1999 PMID: 106 25941

Phytate acts as an inhibitor in formation of renal calculi. 2007 PMID: 17127264

Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: usefulness in renal lithiasis treatment. 1999 PMID: 10625946